Top 10 Seed Investors: Biotechnology/LifeSciences

RankInvestor Name
1SOSV
2IndieBio
3Draper Associates
4ZAKA VC
5Pioneer Fund
6Y Combinator
7Alumni Ventures
8LongGame
9Connecticut Innovations
10Pillar VC

Seed activity in this category runs heavily through the accelerator ecosystem and the funds that follow its cohorts. Clinical data readouts and large pharma acquisition appetite set the pace of investment across biotech, with capital concentrating in firms that can underwrite science. For a company raising at this stage, these are the highest-velocity check writers in the category, and the accelerator and syndicate paths are often the most direct way to reach them.

The CapitalDart directory identifies the right person to contact at each of these firms, with their individual investment criteria.

Rankings reflect investment activity from January 2025 through July 2026 in US and Canada companies, based on transactions matched to the CapitalDart directory. Seed and Early Stage rank by participation, Later Stage by rounds led, Private Equity by control and buyout activity. Updated periodically.